Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures.As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures.We have created a pipeline that combines high-throughput screening in zebrafish with subsequent validation in two mammalia